3D Printing of β-TCP/S53P4 Scaffolds: Physicochemical, Mechanical, and Biological in vitro Evaluation

Abstract: The focus of bone tissue engineering is on the new strategies for developing bioactive and resorbable scaffolds, which have become an alternative to treatment diseases trauma. β-tricalcium phosphate (β-TCP) considered has excellent osteoconductivity. In attempt achieve good densification β-TCP scaffold improve its biological properties, it arises possibility combining this material with S53P4 glass. Several techniques are used produce bioceramic among them, direct ink writing (DIW) a type additive manufacturing based extrusion, allows production customized parts, high complexity reproducibility. This work prepared β-TCP/S53P4 (β-TCP/10-S53P4 = 10% wt β-TCP/20-S53P4 20% S53P4) scaffolds by DIW. ceramic inks showed pseudoplastic behavior 3D-printed similar aspects digital model. Also, 1.6 ± 0.6 MPa 2.1 0.9 MPa) increase in compressive strength when compared (0.9 0.1 MPa). All apatite-mineralization ability SBF after soaking 7 14 days, being that higher apatite formation other scaffolds. Concerning vitro assays, all cell viability. Thus, adequate properties candidates, be engineering.